Autorenportrait
InhaltsangabeList of Contributors.- Basic Mechanisms.- 1. ATP-metabolism in normoxic and ischemic heart.- 2. Development of myocardial energy metabolism.- 3. Principles of fuel metabolism in heart muscle.- 4. Carnitine and cardiac energy supply.- 5. Adenine nucleotides, purine metabolism and myocardial function.- 6. On the role of myocardial AMP-deaminase.- 7. Redox manipulation of free cardiac adenylates and purine nucleoside release.- 8. Regulation of myocardial perfusion by purine metabolites.- 9. Cardiac electrophysiological effects of adenosine.- 10. Acceleration of adenine nucleotide biosynthesis after ischemic insult.- Technical Considerations/Models.- 11. The importance of the determination of ATP and catabolites.- 12. Cardiac energy metabolism probed with nuclear magnetic resonance.- 13. Positron emission tomography and myocardial biochemistry.- 14. Energy metabolism and transport in neonatal heart cells in culture.- 15. Energy metabolism of adult cardiomyocytes.- 16. Ischemia, high-energy phosphate metabolism and sarcomere dynamics in myocardium.- 17. Myocardial function and metabolism during ischemia and reperfusion in anesthetized pigs.- 18. The energetics of "stunned" myocardium.- 19. Energy depletion due to the calcium paradox.- Clinical Implications.- 20. Human purine metabolism.- 21. Diagnosis of ischemic heart disease with AMP-catabolites.- 22. Myocardial high-energy phosphates during open-heart surgery.- 23. Apparent inosine incorporation and concomitant haemodynamic improvement in human heart.- 24. Cardioplegia and calcium entry blockade.- 25. The effect of anesthetics on myocardial adenine nucleotides.- 26. Regeneration of adenine nucleotides in the heart.
