Beschreibung
Thorough coverage of recent developments in the field of solid support oligosaccharide synthesis Solidphase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads. With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as: * Specific oligosaccharide structures used in signal transduction processes * Preparation and screening of glycopeptide libraries * Solidphase carbohydrate synthesis Covering state-of-the-art developments in the field, Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries is a comprehensive resource for bioorganic and organic chemists, biochemists, and medicinal chemists.
Autorenportrait
PETER H. SEEBERGER is Firmenich Assistant Professor of Chemistry at the Massachusetts Institute of Technology in Cambridge, Massachusetts.
